胃癌的环境与遗传危险因素及归因危险度分析

沈孝兵; 张娇; 浦跃朴; 朱良军

胃癌的环境与遗传危险因素及归因危险度分析

Analysis on attributable risk for environmental and genetic risk factors of gastric cancer

摘要

摘要:
目的分析胃癌的环境与遗传危险因素并进行归因危险度评价。
方法采用病例对照研究方法, 对南京地区121例原发性胃癌病例进行环境危险因素调查, 并对相关酶系基因多态性进行分析, 综合评价环境危险因素及遗传危险性在胃癌发生中的归因危险度。
结果在南京地区人群中, 吸烟、食用腌制食品等两种环境危险因素与遗传危险因子细胞色素氧化酶P4502E1(CYP2E1)和N-乙酰化酶(NAT2)的基因型的人群综合归因危险度达69.7%。胃癌的发生主要是环境危险因素与内在遗传特点共同作用的结果。
结论对胃癌的干预应同时考虑环境危险因素和遗传危险性, 在了解个体遗传易感性的基础上, 对其相应的环境危险因素进行干预, 以达到Ⅰ级预防的目的。

Abstract:
Objective To estimate the population attributable risk for environmental and genetic risk factors in the development of gastric cancer.
Methods 1:1 case-control study was carried out in Nanjing area, calculating ARC% for each risk factor of environmental and genetic risk factors in gastric cancer and sAR for all of the risk factors among 121 cases of gastric cancer patients and controls.
Results sAR of tobacco smoking, irregular, pickledfood, family history of digestive system disease accounted for 54.7%.If combined with the genetic risk factors CYP 2E 1 and NAT 2 M 1, sAR increased to 69.7%.The result suggested that genetic polymorphisms and environmental risk factors played co-operated roles in gastric cancer.
Conclusion Preventive strategy should be based on the gentic polymorphisms of different people and environmental risk factors to prevent people from development of gastric cancer.

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