天然β-胡萝卜素拮抗化学致癌物致突变性

田明胜; 郭红卫

天然β-胡萝卜素拮抗化学致癌物致突变性

Study on antimutagenicity of natural β-carotene to chemical carcinogen

摘要

摘要:
目的观察天然β-胡萝卜素对化学致癌物致突变性的拮抗作用。
方法选用改进的体外哺乳类细胞(V₇₉/HGPRT)基因突变试验、改进的小鼠骨髓细胞微核试验和小鼠睾丸染色体畸变试验。
结果在V₇₉/HGPRT基因突变试验中天然β-胡萝卜素可抑制AFB₁(+S₉)和丝裂霉素C(-S₉)对V₇₉细胞的致突变作用; 在体内试验中天然β-胡萝卜素对环磷酰胺诱发的小鼠骨髓细胞微核发生和丝裂霉素C诱发的小鼠睾丸染色体畸变均有明显的抑制作用。
结论天然β-胡萝卜素对化学致癌物致突变性有明显的拮抗效果, 可用于肿瘤防治。

Abstract:
Objective To observe the antimutagenic activity of natural β-carotene to chemical carcinogen.
Methods The modified V₇₉/HGPRT gene mutation test, modified mice bone marow cells micronucleus test and mice testicle cells chromosome aberration test were applied.
Results In V₇₉/HGPRT gene mutation test natural β-carotene could inhibit the mutagenesis of AFB₁(+S₉)and mitomycin C(-S₉)on V₇₉ cells.The micronuclei frequency induced by cyclophosphamidum in mice bone cells and chromosome aberration frequency induced by mitomycin C in mice testicle cells were both inhibited significantly by natural β-carotene.
Conclusion Natureal β-carotene had significantly antimutagenicity to chemcial carcinogen and could be applied on chemopreventing tumor and alleviating adverse effects of chemcial treating drugs.

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