锌和维生素E对糖尿病大鼠内皮细胞保护作用

Protective effects of zinc or/and vitamin E supplement on edothelial cells in diabetic rats

摘要:
目的探讨锌(Zn)和维生素E(VE)对链脲佐菌素(STZ)诱导的糖尿病(DM)大鼠氧化应激及内皮细胞的保护作用。
方法对STZ诱导的糖尿病大鼠模型, 补充Zn和VE, 6周后观察血糖、血清胰岛素、血清总抗氧化能力(T-AOC)、血清丙二醛(MDA)、血浆血栓素B₂(TXB₂)、6-酮-前列腺素F_1α(6-k-PGF_1α)和内皮素(ET)变化。
结果 Zn和VE可以降低血糖、MDA、TXB₂和ET水平, 同时提高血清胰岛素水平、T-AOC和血浆6-k-PGF_1α水平。
结论补充Zn和VE可以减轻糖尿病大鼠氧化应激, 保护内皮细胞, 影响血浆TXB₂、6-k-PGF_1α和ET水平。

Abstract:
Objective To study the protective effects of zinc and vitamin E on oxidative stress and endothelial cells in STZ-induced diabetic rats.
Methods Streptozotocin-induced diabetic rats were supplemented with zinc and vitamtn E for six weeks.Blood glucose, insulin, MDA and T-AOC in serum, plasma levels of TXB₂, 6-k-PGF_1α and ET were examined.
Results In diabetic rats plasma levels of TXB₂ and ET were lowered while blood glucose and MDA were decreased, insulin, T-AOC and plasma levels of 6-k-PGF_1α were increased by zinc and vitamin E supplement.
Conclusion Zinc and vitamin E supplementation reduced oxidative stress, influenced the plasma levels of TXB₂, 6-k-PGF_1α and ET, and had protective effects on endothelial cells in diabetic rats.