Objective   To grasp the depression status of women in the life of menopause for developing mental health education and producing health care measures.

  Methods   Using questionnaire SDS to interview 105 women in the life of menopause, and select 105 men in the life of menopause as control group.

  Results   The depression level of women in the life of menopause was higher than that of men in the life of menopause.

  Conclusion   There was significant difference between man and woman not only in physical, but also in psycho logical, so the woman had tendency to develop endocrinopathy and psychosomatic disorder. Some influencing factors such as marital status, family stauts, insomnia, physical disease, economical status and inter personal relationship were as marital status, family stauts, insomnia, physical disease, economical status and interpersonal relationship were important. It was no doubt to provide necessary psycho logical intervention for the woman in the life of menopause.