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胡以松, 李向培, 杨仕贵, 张国庆, 叶冬青. 基质衍生因子1等基因多态性在人群中的分布[J]. 中国公共卫生, 2004, 20(1): 17-19.
引用本文: 胡以松, 李向培, 杨仕贵, 张国庆, 叶冬青. 基质衍生因子1等基因多态性在人群中的分布[J]. 中国公共卫生, 2004, 20(1): 17-19.
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HU Yi-song, LI Xiang-pei, YANG Shi-gui, . Distribution of SDF 1-3' A, CCR2-64I and-2518MCP-1 polymorphism in population[J]. Chinese Journal of Public Health, 2004, 20(1): 17-19.
Citation: HU Yi-song, LI Xiang-pei, YANG Shi-gui, . Distribution of SDF 1-3' A, CCR2-64I and-2518MCP-1 polymorphism in population[J]. Chinese Journal of Public Health, 2004, 20(1): 17-19.
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基质衍生因子1等基因多态性在人群中的分布

Distribution of SDF 1-3' A, CCR2-64I and-2518MCP-1 polymorphism in population

    摘要
  • 摘要:
      目的   探讨SDF1-3'A、CCR2-64I、-2518MCP-1基因多态性在皖籍汉族人群中的分布.
      方法   运用PCR-RFLP方法确定SDF1-3/A和-2518MCP-1基因多态性, 运用ARMS方法确定CCR2-64I基因多态性.
      结果   皖籍汉族人-2518MCP-1G等位基因突变频率为64%, 高于西班牙人、美国黑人、高加索人, 均有显著性差异(P < 0.01).CCR2-64I等位基因突变频率为25%, 高于美国黑人和高加索人(P < 0.01).SDF1-3'A等位基因突变频率为22%, 高于美国黑人, 但与国内其他地区均无显著性差异(P < 0.05).
      结论   皖籍汉族人-2518MCP-1、CCR2-64I、SDF1-3'A等位基因突变频率有别于其他人种.

     

    Abstract:
      Objective   To investigate the distribution of SDF1-3'A, CCR2-64I and-2518MCP-1 polymorphism in the indigenous Han population of Anhui province.
      Methods   the polymorphism of SDF1-3'A, CCR2-64I and-2518MCP-1 was dete rmined by PCR-RFLP and ARMS(amplification refractory mutation system)respectively.
      Results   the frequency of-2518MPC-1Gin Anhui Han Amerians(P < 0.01).There was significant difference in frequency of CCR2-64I between Caucasian and African Amerians and Anhui Han population(25%), and the frequency of SDF1-3'A (22%)in Anhui Han population was higher than that of African Amerians.But there was no significant difference between Anhui Han population and others areas in China.
      Conclusion   the frequency of-2518MCP-1, CCR2-64I and SDF1-3'A in Anhui Han population was different from others population in the world.

     

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