糖氨酸加压素在高原低氧习服过程中的作用

Function of argining vasopressin in adapting to high altitude and low oxygen

摘要:
目的了解世居高原人群中血浆精氨酸加压素(argininevaso pressin, AVP)的含量变化, 初步探讨AVP在高原低氧习服与适应中的作用。
方法采用放射免疫分析法(RIA)测定世居在海拔2261, 3840, 4280m地区的健康藏族人血浆AVP的含量(pg/L)。
结果同一年龄段, 居住在海拔地区的健康藏族人血浆AVP含量升高(P < 0.01);居住在同一海拔地区的健康藏族人, 随着年龄的增长, 血浆AVP含量也升高(P < 0.01)。
结论 AVP参与了藏族人对高原低氧环境的生物适应过程。

Abstract:
Objective To study the changes of AVP content in native Tibetans at high altitude and discuss its singnificance in adapting of high altitude and low oxygen.
Methods To use the method of radioimmunoassay (RIA) to sutdy the changes of AVP content (pg/L) in serum of the healthy native Tibetans living at 2 261, 3 840, 4 280 meters above sea level.
Results AVP content in serum of the native tibetans increased with same age and living in altitude upward area(P < 0.01).Serum A VP content of the native tibetans increased living in same alt itude increased with aging(P < 0.01).
Conclusion AVP helped the native tibetans cope with their environment of high altitude and low oxygen.