β-胡萝卜素对大鼠肺泡巨噬细胞膜的保护作用

Protective effect of β-carotene on alveolar macrophage of rats caused by cooking oil fume

摘要:
目的探讨β-胡萝卜素对烹调油烟致大鼠肺泡巨噬细胞(AM)膜损伤的保护作用。
方法大鼠吸入烹调油烟, 同时给予β-胡萝卜素, 测定不同染毒时间后大鼠AM膜流动性及肺组织LPO含量。
结果烹调油烟可引起大鼠肺脂质过氧化, 并降低AM膜流动性, 而β-胡萝卜素能使染毒大鼠AM膜流动性明显升高, 肺LPO含量明显下降。
结论 β-胡萝卜素对烹调油烟致大鼠肺脂质过氧化及肺泡巨噬细胞膜损伤具有一定的保护作用。

Abstract:
Objective To study the protective effect of β-carotene on injury of alveolar macrophage of rats induced by cooking oil fume.
Methods Rats were exposed to cooking oil fume and treated with β-carotene at the same time. After treatment, memberane fluidity and content of LPO were detected in different times.
Results Cooking oil fume could cause lipid peroxide of lung in rats and reduce membrane fluidity of alveolar macro phage. While β-carotene could lead to increase of memberane fluidity and decrease the content of LPO significantly.
Conclusion β-carotene played certain protective role in lipid peroxide of lung and injuries of alveolar macrophage induced by cooking oil fume in rats.