深圳市新生儿先天梅毒高危因素调查分析

房思宁; 童秋生; 李放娟; 杜晓红; 郑利雄

深圳市新生儿先天梅毒高危因素调查分析

Analysis on high risk factor of newborn congenital syphilis in Shenzhen

摘要

摘要:
目的探索新生儿先天梅毒高危因素。
方法采用梅毒快速血浆反应素试验(RPR)和梅毒螺旋体颗粒凝集试验(TPPA)筛选阳性(病例组)和阴性(对照组)的新生儿及母亲各53对作为观察对象。
结果病例组53例患儿母亲中曾进行过常规产前检查及梅毒筛查的有12例(22.6%), 显著低于对照组(100.0%, χ²=66.861, P < 0.01)。病例组全部确诊为妊娠合并梅毒, 其中只有7例在20周后接受驱梅治疗(χ²=3.087, P < 0.05), 而对照组发现3例(37%)妊娠梅毒在20周前接受根治。病例组对性传播疾病和艾滋病(STD/AIDS)传播途径知识, 孕期接受产前检查及早期治疗或终止妊娠的正确回答均显著低于对照组(U=5, 408, χ²=29.754及10.82, P_均 < 0.01)。
结论健康教育不够普及, 未能实施产前定期梅毒筛查及早期干预是先天性梅毒的高危因素。

Abstract:
Objective To investigate the high risk factor of newborn congenital syphilis.
Methods 53 positive and negative pairs of new borns and their mothers were selected as case group and control group of observation by rapid plama reagin circle care test(RPR)and treponema pallidum particle agglutination(TPPA).
Results Only 12 sick mothers(22.6%)in case group had antenatal care and syphilis screening, the number was significantly lower than that of the control group (100.0%, χ²=66.861, P < 0.01)and all were pregnant syphilis.Seven mothers in case group had the treatment after 20-week pregnancy(χ²=3.087, P < 0.05), while three mothers in control group who suffered syphilis had thorough treatment before 20-week pregnancy and the rates of the accurate answer on having the antenatal care and early treatment or stopping pragnance were significantly lower than those of the control group(U=5, 408, χ²=29.754 and 10.82, P_ar=0.01).
Conclusion Without enough health education, regular syphilis screening in pregnance and intervention in early stage were high risk factors of new born congenital syphilis.

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