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武冬梅, 孟紫强. SO2吸入对小鼠抗氧化酶及脂质过氧化的影响[J]. 中国公共卫生, 2003, 19(5): 515-517.
引用本文: 武冬梅, 孟紫强. SO2吸入对小鼠抗氧化酶及脂质过氧化的影响[J]. 中国公共卫生, 2003, 19(5): 515-517.
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WU Dong-mei, MENG Zi-qiang. Effects of sulphur dioxide inhalation on activities of GST, G6PD and LPO in mice[J]. Chinese Journal of Public Health, 2003, 19(5): 515-517.
Citation: WU Dong-mei, MENG Zi-qiang. Effects of sulphur dioxide inhalation on activities of GST, G6PD and LPO in mice[J]. Chinese Journal of Public Health, 2003, 19(5): 515-517.
shu

SO2吸入对小鼠抗氧化酶及脂质过氧化的影响

Effects of sulphur dioxide inhalation on activities of GST, G6PD and LPO in mice

    摘要
  • 摘要:
      目的   从SO2吸入对雄性小鼠谷胱甘肽硫转移酶(GST)和葡萄糖-6-磷酸脱氢酶(G6PD)活性及脂质过氧化物(TBARS)的影响, 探讨SO2的毒性作用机制.
      方法   将昆明种纯系雄性小鼠60只随机分成3大组, 每组20只, 每一大组再随机分成SO2吸入组和对照组(SO2吸入组与对照组各10只).吸入组吸入SO2浓度分别为(22±2), (64±3), (148±23)mg/m3.分别检测其脑、肺、心、肝、肾组织中GST和G6PD以及TBARS的变化.
      结果   当SO2浓度为(148±23)mg/m3时, 脑、肺、心、肝、肾组织中GST和G6PD活性均比对照组明显降低(P < 0.01或P < 0.05), 而TBARS水平则升高(P < 0.05或P < 0.01).
      结论   SO2可引起小鼠多种器官组织发生氧化损伤.

     

    Abstract:
      Objective   To investigate the effects of sulphur dioxide inhalation on the activities of GST, G6PD and changes of lipid peroxidation in male mice.
      Methods   Sixty male Kunming strain mice were randomly divided into three large groups, each one is twenty.Each large group was composed of sulphur dioxide inhalation sub-group and control sub-group.Sulphur dioxide inhalation concentrations in three groups were respectively(22±2)mg/m3(low group), (64±3)mg/m3(medium group), (148±23)mg/m3(high group).At the end of experiments the activities of GST, G6PD and content of TBARS were measured in brain, lung, heart, liver, kidney of mice respectively.
      Results   In the case of sulfur dioxide inhalation concentration as 148±23 mg/m3, the activities of GST, G6PD in brain, lung, heart, liver, kidney of mice were observed significantly decreased(P < 0.01 or P < 0.05).The TBARS levels in brain, lung, heart, liver, kidney were significantly increased(P < 0.01 or P < 0.05).
      Conclusion   Sulphur dioxide inhalation can induce injury of mice through the oxidative stress, which was a severe effect of the activity changes of GST, G6PD and TBARS.Sulphur dioxide can induce oxidative damage of many organs in mice.

     

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