急进高海拔ANP与RAAS的相关性研究
Study on relationship between ANP and RAA system in rat carried rapidly into plateau
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摘要:目的 探讨急进高海拔心钠素与肾素-血管紧张素-醛固酮系统的变化及相互关系, 以及二者在急性高原适应中的意义.方法 将30只雄性Wister大鼠, 由海拔10m的青岛市快速带至海拔2261m的西宁市, 再带入海拔3800m的青海省天峻县, 用放射免疫法测定不同海拔大鼠血浆心钠素与肾素、血管紧张素Ⅱ和醛固酮的浓度, 并分析二者的相关性.结果 随海拔递增, (1)大鼠血浆心钠素浓度逐渐升高(P均 < 0.01);(2)肾素及血管紧张素Ⅱ的含量也呈上升趋势(P < 0.01), 仅青岛与西宁的血管紧张素Ⅱ有显著性差异(P < 0.05);(3)醛固酮浓度逐渐下降, 青海与西宁有显著性差异(P < 0.05), 青岛与天峻有显著性差异(P < 0.01), 西宁与天峻无显著性差异(P > 0.05).结论 急进高海拔, 心钠素降低了醛固酮对肾素、血管紧张素Ⅱ的反应性, 使醛固酮处于低水平状态, 上述改变对急性高原适应有非常积极的作用.Abstract:Objective To study the changes of artrial natriurctic factor and renin-angiotension-aldosteron and their relationship when an organism got to the area with high elevation rapidly.Methods Thirty rats were carried rapidly from Qingdao(with an elevation of 10 m)to Xining(2 261 m)and Tianjun(3 800 m).Plasma ANP and rennin, angiotensin Ⅱ aldoster one activities were dynamically tested.Results When rats were carried into plateaus rapidly, their plasma ANP concentrations increased significantly(P < 0.01), concentr ations of renin an angiotensin Ⅱ increased, and the plasma aldosterone concentrations decreased.Conclusion Bioctive substances had important physiological effects on rapid adaptation of organisms to the plateau environment.
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