酒精中毒对家兔氧化—抗氧化平衡的影响

郭坤亮; 安洪; 蒋电明; 邓忠良; 刘传康; 李宏宇

酒精中毒对家兔氧化—抗氧化平衡的影响

Effects of alcoholism on lipid peroxidation and antioxdation of rabbits

摘要

摘要:
目的研究酒精中毒家兔的脂质过氧化和抗氧化系统的变化特点.
方法采用灌胃法给予家兔含50%乙醇的烈性白酒8ml/kg·d6个月, 分别于首次灌胃4、12h和1~6个月灌胃后24h取血动态观察丙二醛(MDA)、超氧化物歧化酶(SOD)、总抗氧化能力(AOA)变化.
结果灌胃4h血中SOD和AOA活性显著降低(P < 0.01), MDA增加(P < 0.01);12h、1、2月时SOD、AOA、MDA变化无显著性差异(P > 0.05).3~6月时SOD和AOA活性逐渐降低(P < 0.05, P < 0.01), 4~6月时MDA逐渐增加(P < 0.05, P < 0.01).
结论短期过量饮酒可引起脂质过氧化反应增强, 抗氧化能力明显减弱, 但仍保持抗氧化代偿能力; 长期大量饮酒导致抗氧化代偿能力障碍.

Abstract:
Objective To investigate the changes and characteristics of rabbit's lipid per oxidation and antioxdation system induced by alcoholism.
Methods To make rabbits alcoholism by using the wine containing 50% of alcohol at dosage of 8 ml/kg·d by pouring into stomach with a plastic tube for 6 months and to observe the changes of the serum super oxide dismutase(SOD), malondialdehyde(MDA), antio xidant ability(AOA)in 4, 12 h and 1-6 months.
Results After pouring 4 hours, the AOA and SOD activity reduced, MDA increased remarkably.Then after 24 hours and in 1-2 months AOA, SOD and MDA did not change significantly.In 3-6 months, AOA and SOD activity decreased, MDA increased in 4-6 month gradually ag ain.
Conclusion Shortter mex cessive intake of wine can remain compensation ability for antioxidation, though may lead to peroxidation and decreaseant oxidation ability, ot herwise, long-ther mexcessive may induce the deficiency of compensation ability for antioxidation.

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