氯化镉对雄性生殖系统生理机能的影响

李建秀; 王晓梅; 杨曙民; 王丽君

氯化镉对雄性生殖系统生理机能的影响

Effect of cadmium chloride on physiological function of male reproductive system

摘要

摘要:
目的探讨氯化镉对雄性生殖系统生理机能的影响.
方法采用职业流行病学调查与动物实验相结合的方法分析镉作业男工精液中的微量元素; 40只小鼠随机分为4组: 氯化镉35, 70, 14.0mg/kg实验组和蒸馏水对照组, 灌胃染毒.观察睾丸的病理组织学改变, 测定睾丸细胞DNA含量和睾丸中微量元素含量.
结果接触组作业男工精液中镉含量明显高于对照组(P < 0.01).实验组小鼠睾丸中镉含量增高(P < 0.05).睾丸的超微结构出现改变, 单倍体细胞DNA含量下降(P < 0.01).
结论氯化镉可影响雄性生殖系统的生理机能, 导致生育力下降.

Abstract:
Objective To study effect of cadmium chloride on physiological function of male reproductive system.
Methods Microelement levels in semen were analysed for male workers exposed to cadmium.40 mice were divided into 4 groups: cadmium chloride 3.5, 7.0, 14.0 mg/kg experimental groups and the control group.They were administrated through the stomachs.The ultrastucture in testis, DNA level in testis cells, microelement levels in testis were observed with occupational epidemiologic investigation and animal experiment.
Results Cadmium levels in semen of male workers exposed to cadmium were higher than the control group(P < 0.01).Cadmium level in testis were higher(P < 0.05).Ultrastucture in testis converted.DNA level of single cell was lower(P < 0.01).
Conclusion Cadmium chloride affected physiological function of male reproductive system, lowered genitality.

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