5种多环芳烃化学物的雌激素样作用研究

Estrogenic effects of 5 polycyclic aromatic hydrocarbons

摘要:
目的评价5种多环芳烃化学物的雌激素样作用.
方法采用大鼠子宫增生实验和MCF-7细胞增殖实验.
结果苯并(a)芘、7, 12-二甲基苯并蒽和2, 3, 6, 7-二苯并蒽不仅引起大鼠子宫湿重明显增加(P < 0.01, P < 0.05), 而且能明显诱导MCF-7细胞增殖(P < 0.01).苯并(a)蒽和1, 2-苯并菲既不能导致大鼠子宫湿重明显增加(P > 0.05), 也不能诱导MCF-7细胞增殖(P > 0.05).
结论苯并(a)芘、7, 12-二甲基苯并蒽和2, 3, 6, 7-二苯并蒽具有明显的雌激素样作用, 而苯并(a)蒽和1, 2-苯并蒽没有检测到雌激素样作用.

Abstract:
Objective To identify the estrogenic effects of 5 poly cyclic aromatic hydrocarbons(PAHs).
Methods Ratuterine weightassay and M CF-7 cell proliferation bioassay.
Results Benz(a)pyrene, 7, 12-dimet hylbenz(a)anthr acene and pentacene not only induced M CF-7 cell proliferation(P < 0 01)but also increased ratuterin weight(P < 0.01).Benz(a)anthracene and chr ysene neither induced M CF-7 cell proliferation(P > 0.05)nor increased rat uterine weig ht(P > 0.05).
Conclusion Benz(a)pyrene, 7, 12-dimethylbenz(a)anthracene and pentacene had significant estrogenic effects.