精神分裂症危险因素的病例对照研究

Case-control study on risk factors of schizophrenia

摘要:
目的探讨精神分裂症发病的主要危险因素, 为精神病防治提供理论依据.
方法应用病例对照研究对101例首发精神分裂症患者和101例正常对照进行1:1配对研究, 通过单因素和多因素分析其危险因素.
结果发现4个主要危险因素, 分别是: 精神病家族史(OR=7.98, 95%CI=2.58~32.58)、内向性格(OR=3.32, 95%CI=1.60~6.94)、遭遇精神创伤事件(OR=5.68, 95%CI=2.01~15.63)、与父母关系不好(OR=4.27, 95%CI=1.03~1774)与精神分裂症的发病显著相关.
结论精神分裂症的发病与遗传和多种环境因素有关.

Abstract:
Objective To investigate the main risk factors of schizophrenia in Xi'an as so to take theoretic foundation to reduce mental illness.
Methods A case-control study was conducted to analyze the main risk factors by univariate and multivariate analyses respectively in 101 first episode pattents with sohizophrenia and 101 normal controls.
Results Four risk factors, positive family history of psychosis(OR=7.98, 95% CI=2.58-32.58), introversive characters(OR=3.32, 95% CI=1.60-6.94), psychosis traumatic events(OR=5.68, 95% CI=2.01-15.63)and tense relationship with parents(OR=4.27, 95% CI=1.03-17.74)had significant correlation with schizophrenia.
Conclusion The development of schizophrenia was caused by both genetic factors and various environmental factors.