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时景璞, 陈祚, 郑力国, 王桂花, 徐占民, 杨志奇, 郭玉凤, 杨俊山, 吴晓音, 梁争论. 小学生接种国产酵母乙肝疫苗3年后免疫效果观察*[J]. 中国公共卫生, 2003, 19(3): 263-264.
引用本文: 时景璞, 陈祚, 郑力国, 王桂花, 徐占民, 杨志奇, 郭玉凤, 杨俊山, 吴晓音, 梁争论. 小学生接种国产酵母乙肝疫苗3年后免疫效果观察*[J]. 中国公共卫生, 2003, 19(3): 263-264.
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SHI Jing-pu, CHEN Zuo, ZHENG Li-guo, . Observation on efficacy of yeast derived hepatitis B vaccines on vaccinated children in three years later[J]. Chinese Journal of Public Health, 2003, 19(3): 263-264.
Citation: SHI Jing-pu, CHEN Zuo, ZHENG Li-guo, . Observation on efficacy of yeast derived hepatitis B vaccines on vaccinated children in three years later[J]. Chinese Journal of Public Health, 2003, 19(3): 263-264.
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小学生接种国产酵母乙肝疫苗3年后免疫效果观察*

Observation on efficacy of yeast derived hepatitis B vaccines on vaccinated children in three years later

    摘要
  • 摘要:
      目的   研究小学生接种酵母乙肝疫苗后的免疫效果。
      方法   在辽宁省北票市各小学校选择一般健康状况良好, HBsAg、抗-HBs、抗-HBc3项指标均为阴性, 免前体温正常的7~9岁儿童, 随机抽取110名, 接种酵母乙肝疫苗。第一针免后3, 7, 12, 24, 36个月采血检测抗-HBs。
      结果   第一针免后各次采血检测抗-HBs阳转率分别为75.7%, 100.0%, 95.1%, 90.7%和875%, 其中24个月时抗-HBs阳转率女性显着高于男性(P < 0.05).抗-HBs几何平均滴度(GMT)分别为43.78, 402.92, 170.43, 155.49和107.57mU/ml, 各次结果显示男女之间抗-HBs滴度无显着性差异。抗-HBs滴度分布仅在T12时男女之间有显着性差异(P < 0.05), 其余各次结果均无显着性差异。
      结论   酵母乙肝疫苗接种儿童具有良好的安全性和免疫原性, 其长期保护作用尚需进一步随访。

     

    Abstract:
      Objective   To evaluate the immune efficacy and safety of yeast-derived hepatits Bvaccines(YDV)on children.
      Methods   One hundred and ten children aged 7 to 9 years old were randomly selected at some schools in Beipiao city, Liaoning Province, whose HBsAg, anti-HBs, anti-HBc were all negtive.They were vaccinated with YDV.Test serum anti-HBs at 3, 7, 12, 24 and 36 months after the first dose YDV was vaccinated.
      Results   Positive seroco nvertion rates of antiHBs were 75.7%, 100.0%, 95.1%, 90.7% and 87.5%, respectively; positive seroconvertion rate of anti-HBs of the female was higher than that of the male(P < 0.05)at 24 month(T 24).Mean geometric titres(GMT)of anti-HBs wer 43.78, 402.92, 170.43, 155.49 and 107.57 mU/ml, respectively; The results indicated that GMT of anti-HBs reached its peak at 7 month(T7);the difference of the GMT of anti-HBs between the male and the female was not significant(P > 0.05); the distribution of anti-HBs titre was significantly different(P < 0.05)only at 12 month(T 12).
      Conclusion   YDVwas safety and immunogenic to vaccinate children.It was necessary to follow up these children to know how long the protective level could last.

     

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