富阳市2002年病毒性肝炎血清流行病学分析

夏自成; 李欢龙; 杜利群

富阳市2002年病毒性肝炎血清流行病学分析

Seroepidemiological investigation on virus hepatitis in Fuyang city in 2002

摘要

摘要:
目的了解富阳市病毒性肝炎流行现状, 为制订防治策略提供科学依据。
方法 2002年10~12月采取分层随机抽样方法, 抽取3个乡镇(街道)6个村368人作为研究对象。用酶联免疫吸附试验(ELISA)检测抗-甲型肝炎病毒(HAV)IgG、抗-丙型肝炎病毒(HCV)IgG、抗-丁型肝炎病毒(HDV)IgG和抗戊型肝炎病毒(HEV)IgG; 用固相放射免疫法(SPRIA)检测乙型肝炎病毒表面抗原(HBsAg)、乙肝病毒表面抗体(抗-HBs)、乙肝病毒核心抗体(抗-HBc)。
结果全市人群抗-HAV、HBV、抗-HCV、抗-HEV的阳性率分别为41.43%, 40.22%, 0.27%, 8.97%;标化阳性率分别为38.15%, 41.67%, 0.11%, 8.29%, 未发现抗-HDV阳性者; 甲、乙肝阳性率有随着年龄增长而升高的趋势; 戊肝阳性率曲线呈中间高, 两头低, 感染者主要集中在30~50岁, 低年龄组与高年龄组感染率均较低; 甲、乙、戊肝阳性率的男、女性差异无统计学意义。
结论富阳市病毒性肝炎呈现不同的血清流行病学特征; 乙肝疫苗纳入计划免疫管理后12年来, 1~15岁儿童HBV阳性率大幅下降。

Abstract:
Objective To know about the epidemic situation of virus hepatitis in Fuyang city and provide theoretic basis for the prevention of virus hepatitis.
Methods Three straitificatio ns including 6 villages and 368 residents were drew out by the method of randomized sampling.Anti-HAV IgG, Anti-HCV IgG and Anti-HEV IgG in blood samples were detected using ELISA method.HBsAg, Anti-HEs and Anti-HBc in blood samples were detected by SPRIA method.
Results The standardized prevalence rate of hepatitis A, hepatitis B, hepatitis Cthepatitis E were 38.15%, 41.61%, 0.11%, and 8.29%, respectively.The standardized prev alence rate of hepatitis A and Bincrease with the age.The prevalence rate of hepatitis E was higher in 30~50 years old people than that in younger and older people.The differences in prevalence rate of hepatitis A, hepatitis B, and hepatitis E between female and male were not significant.
Conclusion The result revealed some epidemic characters of virus hepatitis in Fuyang city.Since the hepatitis B vaccine was brought into expanded programe on immunization(EPI)for twelve years, HBV infection rate had been decreased evidently in 1~15 years old people.

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