启东肝癌中黄曲霉毒素白蛋白加成物水平和p53蛋白表达的研究

A flatox in-album in Adducts levels PS53 overexp ression and Prinary Hepatocellular Carcinom a in Qidong

摘要: 对30例启东肝癌病例和16例对照用竞争抑制放射免疫法检测血清黄曲霉毒素白蛋白加成物，7例血清HBsAg、抗-HBc均阳性的手术病例的石蜡包埋组织用免疫组化法检测p53蛋白表达。结果表明，病例组黄曲霉毒素白蛋白加成物水平在1.07～3.46pmolAFB1/mg白蛋白之间，对照组在0.85～2.99pmolAFB1/mg白蛋白之间，两组比较无显着性差异。6例癌组织、4例癌旁组织p53蛋白表达阳性，且这6例阳性者黄曲霉毒素白蛋白加成物平均水平为1.815±0.622pmolAFB1/mg白蛋白。提示较长时间内病例和对照黄曲霉毒素暴露的蓄积剂量并无显着性差异。

Abstract: Thirty cases of hepato cellular carcinom a(HCC) diagnosed between March and October,1996 and sixteen controls seleeted from othe non-tumo raes and nn-tum orous patlents in Q idong Liver Cancer Institute were enrolled in our study.