Abstract: The purpose of this study is to explore the Lanzhou newbom blood lead level and its relative defermination factors.We conducted ear lobe microblood obstetrical department of our hospital.Using graphitic oven atomic abso rption spectrometry collecting 0.1ml peripheraL blood for measurement.the statical disposal was made by using multiple variables progressive regressive analyses. Result :blood lead Level mean 83.5μg/ L abno rmal detedable rate is 24.27 percent ;the premature infant, low weight infant and infant w ho had history of asphy xia, their blood lead level almost increased; Mother' s blood lead, cultural degree, occupation and some environmental factors had relativity with new born blood lead level.Conclusion :The mean of the city newborn blood lead level is 83.5μg/ L, that signilicantly higher than other provinces and cities, the cases of ≥100μg/ L reached 24.27 percent.Preventing and treating lead poisoning by heathy teaching, environmental intervention, clinical prev ention and treatment.