Abstract: OBJECTIVE To measure the antibio tic susceptibility ofneisser ia gonorrhoeae epidemic strains in Zhanjiang(Guangdong).METHODS 98 gonococcal isolated obtained from 1998 through 1999 in Zhanjiang were tested for theirantibio tic susceptibilities based on the systemic identification.The inhibitory zo ne diameters (mm)and the minimum inhibito ry concenrations(MICs)of penicillinte tracycline, spectinomy cin, ceftr iaxone and ciprofloxacin were determined by using disk diffusion and agar dilution methods, respectively.Then difined the susceptibilities of all these isolates using the MCCLS criteria.RES ULTS The percentages of gonococci resitant strains to penicillin, tetracycline, spectinomy cin,ceftriaxion and ciproflox acin were 32.65%、69.39 %、8.16%、 13.27 % and 82.65 % by using disk diffusion metod.At the same tiome, the percentages of resistant strains by using ag ar dilutiion method were 23.91 %、49.46 %、11.11% 、16.48% and 59.34 % respectiv ely.CONCLUSION The resistant strains of contemporary gonococci in Zhanjiang were serious.especially the ciprofloxacin resistance. By the way.contimued active survillance is needed to detect and contro l the spread of ceftr iaxo ne and spectinomycin resistant Neisseria g onor rhoeae.Strains to Antibiotics.