Chemotherapeutic sensitizing effect of peracetate EGCG on hepatocellular carcinoma cells

ObjectiveTo study the chemotherapeutic sensitizing effect of epigallocatechin gallate(EGCG)and peracetate EGCG(AcEGCG)on hepatocellular carcinoma cells SMMC-7721.MethodsThe SMMC-772 cells were treated with daunorubicin(DNR)and/or EGCG(AcEGCG).The cytotoxicity of the compounds was detected by 3-4,5-dimethylthiazol-2-yl2,5-diphenyltetrazolium bromide(MTT)method.ResultsAcEGCG(35.0μmol/L,100.0μmol/L)combined with DNR(0.9μmol/L)could increased the inhibitive rate of SMMC-7721 cells from 48.1% to 67.0% and from 65.0% to 78.9% for EGCG combined with DNR,respectively.ConclusionAcEGCG combined with DNR could enhance the cytotoxicity of AcEGCG on SMMC-7721 cells than that of EGCG in some given dosage.