Objective To examine relationships between partial androgen deficiency and glucose and lipid profile in middle-aged and elder men and to provide a reference for the prevention and control of partial androgen. deficiency in aged men (PADAM).
Methods Blood samples were collected from 4 291 men aged≥40 years selected from 7 153 male health examinees aged≥20 years from the First Affiliated Hospital of Wenzhou Medical University between January 2011 and October 2015 and were divided into a case group and a control group based on their serum testosterone (T) levels and clinical symptoms of PADAM. Serum testosterone, blood glucose and lipid profiles were determined in all the participants and compared between the case and control group; correlations between the occurrence of PADAM and glucose and lipid profiles were analyzed.
Results Of the 4291 men aged≥40 years, 754 (17.57%) were identified as PADAM cases. Compared with those of the controls, the cases with PADAM had significantly higher blood glucose (GLU, 5.70 vs. 5.50 mmol/L), triglyceride (TG, 2.02 vs. 1.60 mmol/L), non high density lipoprotein cholesterol (non-HDL-C, 3.87 vs. 3.78 mmol/L), plasma atherogenic index (AIP, 2.29 vs. 2.14 presented as logarithmic value of AIP plus 100), arterial stiffness index (ASI, 3.57 vs. 3.27 ) (all P < 0.05) and significantly lower serum testosterone (9.67 vs. 15.35 nmol/L) and high density lipoprotein cholesterol (HDL-C, 2.84 vs. 2.96 mmol/L) (all P < 0.01). Serum testosterone level was correlated reversely with GLU, TG, non-HDL-C, AIP, and ASI (all P < 0.001) and positively with HDL-C (r = 0.17, P = 0.002). The results of logistic regression analysis showed that age, GLU,and AIP were the risk factors of PADAM.
Conclusion PADAM is correlated with glucose and lipid profiles; low serum testosterone can lead to elevated GLU, TG, non-HDL-C, AIP, and ASI l and decreased HDL-C among middle-aged and elder men.
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