Objective To assess subchronic toxicity of huanghuali (Dalbergia odorifera T. Chen) tea in rats.
Methods A ninety-day feeding experiment was performed in 140 specific pathogen free Sprague-Dawley (SD) rats according to the Food Safety Toxicology Evaluation Procedures and Methods – 2015 Edition.
Results During the experiment, all the rats were generally in good condition and no death was observed. Compared with those of the control rats, there was no significant difference in weekly body weight, food intake and food utilization rate of final phase, hematology and serum biochemical indexes, organ weight and organ/body weight ratio in rats of all the dose groups (P > 0.05). No remarkable changes were observed in urinary routine indicators, eye examination and gross anatomy, and histopathological examinations.
Conclusion Huanghuali tea shows no obvious toxicity, with a no observed adverse effect level (NOAEL) of 22.22 g/kg·bw, in rats.
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