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Volume 37 Issue 12
Dec.  2021
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ZHANG Dan-dan, ZHU Qiu-shuang, LIU Jin-xiao, . Effect of different dietary carbohydrate/fat ratios on aging biomarkers under the same energy and protein intake in healthy people: a metabonomics study[J]. Chinese Journal of Public Health, 2021, 37(12): 1778-1782. doi: 10.11847/zgggws1131740
Citation: ZHANG Dan-dan, ZHU Qiu-shuang, LIU Jin-xiao, . Effect of different dietary carbohydrate/fat ratios on aging biomarkers under the same energy and protein intake in healthy people: a metabonomics study[J]. Chinese Journal of Public Health, 2021, 37(12): 1778-1782. doi: 10.11847/zgggws1131740

Effect of different dietary carbohydrate/fat ratios on aging biomarkers under the same energy and protein intake in healthy people: a metabonomics study

doi: 10.11847/zgggws1131740
  • Received Date: 2020-07-22
    Available Online: 2021-08-12
  • Publish Date: 2021-12-13
  •   Objective   To explore the relationship between different carbohydrate/fat intake ratio and aging biomarkers under normal energy and protein intake in healthy people.   Methods  Form 4 973 adult residents participating in Harbin Cohort Study on Diet, Nutrition and Non-Communicable Chronic Diseases conducted in 2015, we selected 90 healthy people reporting normal dietary protein and energy intake but without personal and family history of chronic disease and divided them into three groups (30 in each group): normal control (N), high fat (HF) and high carbonhydrate (HC) group. Ultrahigh performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC-Q-Tof-MS) was used to detect metabolic fingerprints of plasma samples of the participants. Principal component analysis (PCA) and partial least squares discriminant analysis (PLS-DA) were employed to analyze differences in metabolites among the participants of different age group. Aging biomarkers were screened out according to the values of variable importance in the projection (VIP) and variation ratio obtained by PLS-DA model, and changes in the aging biomarkers in different dietary groups were analyzed.  Results  The results of UPLC-Q-Tof-MS showed that all the study groups could be distinguished accurately under PLS-DA mode and there were significant differences in plasma metabolic mode. Five aging biomarkers were identified; among which, 12 (s)-hpete, aminoadipic acid and 3-hydroxynonylcarnitine increased with age, while L-leucine and dehydroe-piandrosterone sulfate decreased with age. In comparison with those of the N group, the concentrations of L-leucine and dehydroepiandrosterone sulfate of the HF and the HC group decreased, but the concentrations of 12 (s)-hpete, aminoadipic acid and 3-hydroxynonylcarnitine of the two groups increased. Compared with the HF group, the HC group had decreased L-leucine and dehydroepiandrosterone sulfate but increased 12 (s)-hpete, aminoadipic acid and 3-hydroxynonanoylcarnitine. The results suggested that both high-fat and high carbohydrate could promote aging to some extent, and the effect of high carbohydrate on aging is more obvious.  Conclusion  Under the same energy and protein intake, high-fat and high carbohydrate intake are not conducive to healthy life span; compared with high-fat intake, high carbohydrate intake is easier to promote aging process and shorten life expectancy.
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  • [1]
    Fontana L, Partridge L. Promoting health and longevity through diet: from model organisms to humans[J]. Cell, 2015, 161(1): 106 – 118.
    [2]
    Lundsgaard AM, Holm JB, Sjøberg KA, et al. Mechanisms preserving insulin action during high dietary fat intake[J]. Cell Metabolism, 2019, 29(1): 50 – 63. e4.
    [3]
    Da Silva-Santi L G, Antunes M M, Caparroz-Assef S M, et al. Liver fatty acid composition and inflammation in mice fed with high-carbohydrate diet or high-fat diet[J]. Nutrients, 2016, 8(11): 682.
    [4]
    Solon-Biet SM, Mitchell SJ, Coogan SCP, et al. Dietary protein to carbohydrate ratio and caloric restriction: comparing metabolic outcomes in mice[J]. Cell Reports, 2015, 11(10): 1529 – 1534.
    [5]
    Mirmiran P, Esmaillzadeh A, Azizi F. Diet composition and body mass index in Tehranian adults[J]. Asia Pacific Journal of Clinical Nutrition, 2006, 15(2): 224 – 230.
    [6]
    Johnson CH, Ivanisevic J, Siuzdak G. Metabolomics: beyond biomarkers and towards mechanisms[J]. Nature Reviews Molecular Cell Biology, 2016, 17(7): 451 – 459.
    [7]
    程义勇. 《中国居民膳食营养素参考摄入量》2013修订版简介[J]. 营养学报, 2014, 36(4): 313 – 317.
    [8]
    刘莉, 张卿, 宋崑, 等. 天津居民膳食模式与血清尿酸相关性的研究[J]. 中华健康管理学杂志, 2017, 11(1): 40 – 46.
    [9]
    Colman RJ, Anderson RM, Johnson SC, et al. Caloric restriction delays disease onset and mortality in rhesus monkeys[J]. Science, 2009, 325(5937): 201 – 204.
    [10]
    Apfeld J, O'Connor G, McDonagh T, et al. The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans[J]. Genes and Development, 2004, 18(24): 3004 – 3009.
    [11]
    邓艳. 限制饮食对延缓衰老的影响[J]. 养生月刊, 2005, 26(4): 341 – 345.
    [12]
    邢晓然, 余振球. 年龄对脂质代谢的影响[J]. 中西医结合心脑血管病杂志, 2015(2): 245 – 246.
    [13]
    Shimizu M, Terakura D, Kochi T, et al. Preventive effects of branched-chain amino acid supplementation on the spontaneous development of hepatic preneoplastic lesions in C57BL/KsJ-db/db obese mice[J]. Carcinogenesis, 2012, 33(12): 2499 – 2506.
    [14]
    Chen KH, Chen YL, Tang HY, et al. Dietary leucine supplement ameliorates hepatic steatosis and diabetic nephropathy in db/db mice[J]. International Journal of Molecular Sciences, 2018, 19(7): 1921.
    [15]
    Lane MA, Ingram DK, Ball SS, et al. Dehydroepiandrosterone sulfate: a biomarker of primate aging slowed by calorie restric-tion[J]. The Journal of Clinical Endocrinology and Metabolism, 1997, 82(7): 2093 – 2096.
    [16]
    Sell DR, Strauch CM, Shen W, et al. 2-Aminoadipic acid is a marker of protein carbonyl oxidation in the aging human skin: effects of diabetes, renal failure and sepsis[J]. Biochemical Journal, 2007, 404(2): 269 – 277.
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