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Volume 37 Issue 11
Nov.  2021
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LI Meng-ying, GUO Huan. Detection and influencing factors of peripheral blood mitochondrial DNA copy number: a review[J]. Chinese Journal of Public Health, 2021, 37(11): 1704-1708. doi: 10.11847/zgggws1132373
Citation: LI Meng-ying, GUO Huan. Detection and influencing factors of peripheral blood mitochondrial DNA copy number: a review[J]. Chinese Journal of Public Health, 2021, 37(11): 1704-1708. doi: 10.11847/zgggws1132373

Detection and influencing factors of peripheral blood mitochondrial DNA copy number: a review

doi: 10.11847/zgggws1132373
  • Received Date: 2020-09-08
    Available Online: 2021-08-12
  • Publish Date: 2021-11-10
  • Peripheral blood mitochondrial DNA copy number (mtDNAcn) is a novel biomarker reflecting oxidative stress status in body. Emerging epidemiological evidences have reported associations of peripheral blood mtDNAcn with major chronic diseases such as cardiovascular diseases, Parkinson's disease, and cancer. It is of great importance to develop methods for measuring peripheral blood mtDNAcn and to identify their risk factors, which could help to promote prevention of chronic diseases. In this study, we introduce detection methods of mtDNAcn and give an outline review on the potential influencing factors of peripheral blood mtDNAcn, aiming to present evidences for identification of peripheral blood mtDNAcn as an early biomarker and to provide technical support for the prevention of chronic diseases.
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