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Volume 38 Issue 3
Feb.  2022
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ZHANG Shi-jie, CHEN Wei-hong, LIU Wei-min, . Effect of comprehensive intervention on hepatitis B in Luohu district of Shenzhen city[J]. Chinese Journal of Public Health, 2022, 38(3): 276-279. doi: 10.11847/zgggws1134656
Citation: ZHANG Shi-jie, CHEN Wei-hong, LIU Wei-min, . Effect of comprehensive intervention on hepatitis B in Luohu district of Shenzhen city[J]. Chinese Journal of Public Health, 2022, 38(3): 276-279. doi: 10.11847/zgggws1134656

Effect of comprehensive intervention on hepatitis B in Luohu district of Shenzhen city

doi: 10.11847/zgggws1134656
  • Received Date: 2021-03-15
    Available Online: 2021-11-16
  • Publish Date: 2022-03-10
  •   Objective  To analyze carrier rate and infection incidence of hepatitis B virus (HBV) and HBV infection-related mortality rate among residents of Luohu district, Shenzhen city in 2010 and 2020 for evaluating the effect of comprehensive prevention and control of HBV infection in the region.   Methods  With stratified multistage cluster random sampling, HBV carrier was surveyed in 2010 and 2020 among residents in Luohu district (a designated demonstration region for viral hepatitis B [HB] prevention and control from 2006). Annual data for years of 2010 – 2020 on HBV infection incidence, HBV infection-related mortality, and demographics were collected simultaneously for Luohu district and Longgang district (a region in the same city but without implementation of comprehensive intervention on HB) for comparative study. Descriptive epidemiology was adopted in analyses on situations and changing trend of HBV carrier, infection and HBV infection-related mortality.   Results  Compared to those in 2010 (the early implementation stage of comprehensive intervention on HBV infection), the standardized serum positive rate of HBV surface antigen (HBsAg) declined significantly (8.74% vs. 6.91%, P < 0.01) and the incidence rate of HBV infection decreased by 96.88% (2.88/100 000 vs. 0.09/100 000), but the standardized mortality rate of HB-related diseases fluctuated not significantly (5.36/100 000 vs. 5.67/100 000, P = 0.561) among residents of Luohu district in 2020. For the years of 2010 – 2020, the annual incidence rate of HBV infection in Luohu district were all significantly lower than those in Longgang district (all P < 0.05). In comparison with that of Longgang district, the Luohu district's standardized mortality of HB-related diseases was higher during 2010 – 2015, basically the same in 2016 and 2017, but significantly lower for years of 2018 – 2020 (P < 0.05 for all).   Conclusion  Ten years after the implementation of the comprehensive prevention and treatment on viral hepatitis B in Luohu district, remarkable results have been achieved and the model for comprehensive intervention on viral hepatitis B in communities could be promoted in China.
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