Burden of cardiovascular disease attributable to dietary lead exposure among adults in China, 2017

LI Yi-ling; YAN Yi-zhong; LIU Jia-lin

doi:10.11847/zgggws1137343

Volume 38 Issue 5

May 2022

Turn off MathJax

Article Contents

Article Navigation > Chinese Journal of Public Health > 2022 > 38(5): 557-562

LI Yi-ling, YAN Yi-zhong, LIU Jia-lin, . Burden of cardiovascular disease attributable to dietary lead exposure among adults in China, 2017[J]. Chinese Journal of Public Health, 2022, 38(5): 557-562. doi: 10.11847/zgggws1137343

Citation:

LI Yi-ling, YAN Yi-zhong, LIU Jia-lin, . Burden of cardiovascular disease attributable to dietary lead exposure among adults in China, 2017[J]. Chinese Journal of Public Health, 2022, 38(5): 557-562. doi: 10.11847/zgggws1137343

Citation:

PDF( 582 KB)

Burden of cardiovascular disease attributable to dietary lead exposure among adults in China, 2017

doi: 10.11847/zgggws1137343

1.
Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province 430030, China

Received Date: 2021-11-03
Available Online: 2022-04-29
Publish Date: 2022-05-20

Abstract

Abstract

Objective To analyze the burden of cardiovascular disease (CVD) attributable to dietary lead among Chinese adults aged 18 years and over in 2017, and to provide a reference for assessing health hazards caused by exposure to lead in diet. Methods The data on disease burden of CVD among residents in China were extracted from the Global Burden of Disease Study 2017 (GBD 2017). The information relevant to blood lead (BLL), bioavailability of lead ingestion through digestive tract and respiratory tract for Chinese adults and lead concentrations in food, air, and drinking water were retrieved form literatures published from January 2000 to July 2020 via searching PubMed, Web of Science, China National Knowledge Infrastructure (CNKI), WanFang Database, and China Biology Medicine Database (CBMdisc). Population attribution fraction (PAF) was calculated using comparative risk assessment to estimate the burden of cardiovascular disease due to lead exposure. Based on the principle of integrated exposure uptake biokinetic (IEUBK) model, the contribution rate of dietary lead exposure to BLL was evaluated. Results The pooled mean BLL for Chinese adults was 5.23 μg/dL (5.96 μg/dL for males and 4.90 μg/dL for females). In 2017, the total disability-adjusted life years (DALYs) of cardiovascular disease attributable to lead exposure in Chinese adults was 3.2396 million years and the standardized attributable DALY rate was high for the adults in Sichuan, Yunnan, and Hunan province, resulting in the loss of 635.00, 633.62, and 547.36 healthy life years per 100 000 people, respectively. The dietary lead was a major contributor to the adults′ lead exposure, accounting for 57.01% and 58.60% of total lead exposure in male and female adults. The DALYs of cardiovascular disease attributed to dietary lead exposure was 1.8634 million, including 602.3 thousand DALYs of ischemic heart disease, 997.0 thousand DALYs of stroke, and 193.7 thousand DALYs of hypertensive heart disease. Conclusion For Chinese adults in 2017, lead exposure contributes to a significant ratio of burden of cardiovascular disease, and diet is a primary source of lead exposure.
- lead exposure,
- cardiovascular disease,
- disease burden,
- dietary source,
- adults,
- China

FullText(HTML)

References(27)

References

[1]	Boskabady M, Marefati N, Farkhondeh T, et al. The effect of environmental lead exposure on human health and the contribution of inflammatory mechanisms, a review[J]. Environment Inter-national, 2018, 120: 404 – 420. doi: 10.1016/j.envint.2018.08.013
[2]	Budtz-Jørgensen E, Bellinger D, Lanphear B, et al. An inter-national pooled analysis for obtaining a benchmark dose for environmental lead exposure in children[J]. Risk Analysis, 2013, 33(3): 450 – 461. doi: 10.1111/j.1539-6924.2012.01882.x
[3]	Chowdhury R, Ramond A, O'Keeffe LM, et al. Environmental toxic metal contaminants and risk of cardiovascular disease: syste-matic review and meta-analysis[J]. BMJ, 2018, 362: k3310.
[4]	Navas-Acien A, Guallar E, Silbergeld EK, et al. Lead exposure and cardiovascular disease – a systematic review[J]. Environmental Health Perspectives, 2007, 115(3): 472 – 482. doi: 10.1289/ehp.9785
[5]	Zhou MG, Wang HD, Zeng XY, et al. Mortality, morbidity, and risk factors in China and its provinces, 1990 – 2017: a systematic analysis for the Global Burden of Disease Study 2017[J]. Lancet, 2019, 394(10204): 1145 – 1158. doi: 10.1016/S0140-6736(19)30427-1
[6]	李茜瑶, 周莹, 黄辉, 等. 疾病负担研究进展[J]. 中国公共卫生, 2018, 34(5): 777 – 780. doi: 10.11847/zgggws1118319
[7]	Shaffer RM, Sellers SP, Baker MG, et al. Improving and expanding estimates of the global burden of disease due to environmental health risk factors[J]. Environmental Health Perspectives, 2019, 127(10): 105001. doi: 10.1289/EHP5496
[8]	邹天森, 张金良, 陈昱, 等. 中国部分城市空气环境铅含量及分布研究[J]. 中国环境科学, 2015, 35(1): 23 – 32.
[9]	Pan LB, Wang Z, Peng ZQ, et al. Dietary exposure to lead of adults in Shenzhen city, China[J]. Food Additives and Contaminants: Part A, 2016, 33(7): 1200 – 1206. doi: 10.1080/19440049.2016.1200750
[10]	吴永宁, 赵云峰, 李敬光. 第五次中国总膳食研究[M]. 北京: 科学出版社, 2018.
[11]	环境保护部. 中国人群暴露参数手册(成人卷)[M]. 北京: 中国环境出版社, 2013.
[12]	Nordberg GF, Fowler BA, Nordberg M. Handbook on the Toxic-ology of Metals[M]. 3rd ed. New York: Academic Press, 2007.
[13]	中华人民共和国国家统计局. 中国统计年鉴2017[M]. 北京: 中国统计出版社, 2017.
[14]	Yan YZ, Yang SL, Zhou YJ, et al. Estimating the national burden of mild intellectual disability in children exposed to dietary lead in China[J]. Environment International, 2020, 137: 105553. doi: 10.1016/j.envint.2020.105553
[15]	Fewtrell L, Kaufmann R, Prüss-Üstün A. Lead: assessing the environmental burden of disease at national and local levels[R]. Geneva: WHO Document Production Services, 2003.
[16]	GBD 2017 Risk Factor Collaborators. Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990 – 2017: a systematic analysis for the Global Burden of Disease Study 2017[J]. Lancet, 2018, 392(10159): 1923 – 1994. doi: 10.1016/S0140-6736(18)32225-6
[17]	胡佳, 陈建伟, 周宜开. IEUBK模型的应用概况及其本土化的初步探讨[J]. 环境与健康杂志, 2013, 30(7): 655 – 658.
[18]	Li MM, Cao J, Xu J, et al. The national trend of blood lead levels among Chinese children aged 0 – 18 years old, 1990 – 2012[J]. Environment International, 2014, 71: 109 – 117. doi: 10.1016/j.envint.2014.06.005
[19]	Ericson B, Dowling R, Dey S, et al. A meta-analysis of blood lead levels in India and the attributable burden of disease[J]. Environ-ment International, 2018, 121: 461 – 470. doi: 10.1016/j.envint.2018.08.047
[20]	Lanphear BP, Rauch S, Auinger P, et al. Low - level lead exposure and mortality in US adults: a population - based cohort study[J]. The Lancet Public Health, 2018, 3(4): e177 – e184. doi: 10.1016/S2468-2667(18)30025-2
[21]	刘巍. 中国铅酸蓄电池行业清洁生产和铅元素流研究[D]. 北京: 清华大学, 2016.
[22]	Kosnett MJ, Wedeen RP, Rothenberg SJ, et al. Recommendations for medical management of adult lead exposure[J]. Environmental Health Perspectives, 2007, 115(3): 463 – 471. doi: 10.1289/ehp.9784
[23]	Menke A, Muntner P, Batuman V, et al. Blood lead below 0.48 μmol/L (10 μg/dL) and mortality among US adults[J]. Circulation, 2006, 114(13): 1388 – 1394. doi: 10.1161/CIRCULATIONAHA.106.628321
[24]	Chen C, Li Q, Nie XM, et al. Association of lead exposure with cardiovascular risk factors and diseases in Chinese adults[J]. Environmental Science and Pollution Research, 2017, 24(28): 22275 – 22283. doi: 10.1007/s11356-017-9884-6
[25]	Hough RL, Breward N, Young SD, et al. Assessing potential risk of heavy metal exposure from consumption of home - produced vegetables by urban populations[J]. Environmental Health Perspec-tives, 2004, 112(2): 215 – 221. doi: 10.1289/ehp.5589
[26]	Mielke HW. Nature and extent of metal - contaminated soils in urban environments (keynote talk)[J]. Environmental Geochemistry and Health, 2016, 38(4): 987 – 999. doi: 10.1007/s10653-016-9792-6
[27]	U. S. Food and Drug Administration. Lead in Food, Foodwares, and Dietary Supplements[EB/OL]. (2020 – 02 – 27) [2021 – 07 – 29]. https://www.fda.gov/food/metals-and-your-food/lead-food-foodwares-and-dietary-supplements.