Studies on Effects of Organophosphates on GABA Receptors of the Rat Brain in Vitro

To study the mechanism of GABA receptor of organophosphates(OP)in vitro in order to give the evidencesof studying Op in vivo.Experiment use the model of rat's microsac to observe the change of ³HGABA bining to GABA receptor with diazino,soman,DFP,fenitrothion,azinphos ethyl,ethion acting in vitro.The ³HGABA binding of rat's microsac was significant decreased when 10mmol/L diisopropylfluorophosphate(DFP),fenitrothion,azinphos ethyl or 5mmol/L diazinon,soman were acted on the rat's microsac in virto(P<0.01).0.1mmol/L soman or 0.5mmol/L diaznon were acted on the rat's microsac in vitro,the ³HGABA binding were still significant decreased(P<0.05).The binding of GABA receptor was decreased when organophosphates were acted on the rat's microsac in vitro.