The Effects of Fluoride on Contents of NO in Organism

Using the method of subchronic animal experiment the effects of fluoride on contents of NO in organism were observed.The contents of urine F- and feces F- in fluride-treated group were significantly higher than that in control group.Compared with control group,The GSH contents of fluride-treated group in blood and all kinds of organ decreased significantly(P<0.05). The contents of NO₂^-/NO₃^- in kidney and brain of fluor idetreated group were significantly lower than that of control group, but that in heart and liver were significantly higher than that of control group.The results showed that fluoride could reduce the levels of GSH and induce the abnormal synthesis of NO in organism.NO maybe involved in the mechanism of fluorosis.