The Effect of Lycopene on Cell Growth of Human Prostate Carcinoma Cell

ObjectiveTo investigate the influence of lycopene on cell growth of prostate carcinoma cell line and apoptosis.MethodsTime and dose effects of lycopene were detected using MTT assay;The influences in the cell cycle and the apoptosis were obsersved through flow cytometry.ResultsLycopene could inhibit the growth of DU-154 cell line with a dose-effect The biggest rate of cell growth inhibition is up to 78% in those treated with lycopene for 4 days.Lycopene can influence the cell cycly of CU-145 and apoptosis.But ithas not been found in LNCaP cell line.ConclusionLycopen inhibits DU-145 cell line in vitrol,and the mechanism may be related to the influence in the cell cycle and induction of apoptosis.Ithas been demonstrated that androgen indepent cell line(DU-145)are more sensitive to Lycopene than androgen dependent cell line(LNCaP).