Toxic Effect of γ-irradiation on Circadian Rhythms of cAMP and cGMP in Mouse Serum

Objective The circadian rhythms of cAMP、cGMP and the ratio of cAMP/cGMP were determined in serum of mice.Methods To measure the contents of cAMP、cGMP and cAMP/cGMP ratio in serum in different adminstractive schedules.Results Different rhythms of cAMP and cGMP were found in mice,according to different administrative schedules in a period of 24 hours.After 0.5Gy γ-irradiation,the level of cAMP and cGMP increased.Upon 3.0 Gy of γ-irradiation,the contents of cAMP and cAMP/cGMP ratio were all increased,while the contents of cGMP was decreased in serum.The acrcphase of the cAMP and cAMP/cGMP ratio were advanced at time of 8:00,and that of were delayed at 20:00.Conclusion It can be concluded that the content and rhythm of cAMP、cGMP and cAMP/cGMP ratio changed in different ways upon expouse to irradiation at different doses and times.