Antioxidation Defense and Selenium Metabolism of Ethanol Dependent Rats

Objective To approach the rat's tissue injure feature and sensitive index of ethanol dependence.Methods To form ethhanol dependent rats by using 52% Erguotou(Beijing Hongxingpai) 2.5,5.0 g/kg·weight ingestion for 6 weeks and to observe the relationship between the degree of hepatocellular injure(GPT activity increase) and antioxidation defense and selenium metabolism.Results The GPT activity of 5.0 g/kg·weight dose group was remarkably higher than that of 2.5 g/kg·weight group and control group,the defense of antioxidation and selenium content in blood,liver and brain decreased remarkably(P _av <=0.01).The SOD activity in 2.5g/kg·weight group presented reversal.Conclusion The liver was the target tissue of ethanol toxic injure,LPO,GSH-Px and Se were sensitive index of alcohol's early stage toxic injure.