Restraining effect of ebselen on peroxidizing damage caused by alcohol to rat

  Objective   To realize the restraining effect of the synthesized ebselen(Ebs)on the peroxidizing damage.

  Methods   5.0 g/(kg·d)of alcohol and 0.5-25.0 mg/(kg·d)of Ebs were given to the rats'stomach, and the activity of the glutathione peroxidase(GPx)in blood plasma and the amount of the lipid peroxide(LPO)in blood serum and the ratio were observed one time respectively at the end of the third week and the sixth week.

  Results   Compared with the alcohol group, the GPx's activity of the Ebs group whose dose was over 5.0 mg/kg increased and the amount of LPO decreased at the end of the third week, the GPx's activity of the Ebs whose dose was over 5.0 mg/kg and the change of the amount of LPOgroup had the dose-response relatio n significantly at the end of the sixth week, the ratio between the GPx and LPO increased apparently.

  Conclusion   The synthesized Ebs can restrain the oxidizing damage, and the effective dose was 5.0 g/(kg·d)of Ebs(3w)and 0.5 g/(kg·d)of Ebs(6 w).