Changes of activities of apoptosis-related enzymes in hippocampal slice in acute lead-poisoned mice

GAO Mingqi; ZHANG Tianbiao; SUN Liguang

doi:10.11847/zgggws2005-21-04-34

GAO Mingqi, ZHANG Tianbiao, SUN Liguang, . Changes of activities of apoptosis-related enzymes in hippocampal slice in acute lead-poisoned mice[J]. Chinese Journal of Public Health, 2005, 21(4): 440-441. DOI: 10.11847/zgggws2005-21-04-34

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Changes of activities of apoptosis-related enzymes in hippocampal slice in acute lead-poisoned mice

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Objective To explore changes of hippocampal calpain and calcineurin activities in Pb²⁺ damaged mouse and effect of(D-(-)-2-A mino-5-phosphonopentanoic acid)AP-5 on it.
Methods By means of hippocampal slice to observe changes of calpain and calcneurin act ivities in mouse.
Results Pb²⁺ resulted in increases of calpain and calcineur in activities in mouse hippo campal slices, and AP-5 could antagonize preceding changes.
Conclusion AP-5 can antagonize the increase of calpain and calcineurin activities of mouse induced by Pb ²⁺.

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Changes of activities of apoptosis-related enzymes in hippocampal slice in acute lead-poisoned mice

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