Protection effect of selenium and organo-germanium-132 on ethanol injury in rats

  Objective   To appro ach protection of selenium and organo-germanium-132 on the rat's tissue injury of alcoholism.

  Methods   Etheanol dependent rats were formed by using 52%, 51 0 g/(kg·bw)Erguotou(Beijing Hongxing).The rats was ingested for 3 months and the contents of malondialdehy de(MDA), glutathione(GSH)and activity of supero xide dismutase(SOD)in liver, renal, brain and Serum were detected.

  Results   The content of MDAwas decreased(P < 0101), the contents of GSHand the activit ies of superox ide dismitase(SOD)were increased in tissue and serum among alcohol+Se, alcoho l+Ge-132, alcoho l+Se+Ge-132 and alcohol groups(P < 01.05).

  Conclusion   Selenium and organo-germanium-132 can inhibit the injury of over-dose alcohol to body by elevating contents of GSH, activities of SOD.