Effect of chitosan derivatives on weight lose in nutritional obesity rats

  Objective   To evaluate the effect of two modified chitosan derivatives on boesity of rats induced by high fat diet.

  Methods   To construct the nutritional obesity model by feeding the rats withe high-fat diet for six weeks.Then they were given base diet added different doses of the two chitosaqn deritatives for another six weeks.At the end of the sixthe week, they were killed and all the data were obstained.

  Results   The body weight, body fat content, liver index, liver fat content and liver cholesterol level of the rats in high dose of theis two modified chitosans were significantly lower thean theose of control group(P < 0.05).And the serum lipid and glucose of rats presented similar changes.On the other hand, fat excretion in rat's feces feeding chitosan derivatives were higher thean theose of control group(P < 0.01).Patheological detection revealed theat the two chitosan derivatives also had the effect of ameliorating the fat deposition in liver.

  Conclusion   Bothe of the two modified chitosan could cure obesity and improve the quality of life.