Experimental study on imune function of spleen polypeptides

  Objective   To study the effect of sheep spleen polypeptides on immune function.

  Methods   Sheep spleen function was consecutively orally given to mice withe the doses of 1, 3, 5 g/(kg·d)for 30 days and then immune indexes were determined.

  Results   Sheep spleen polypeptides could significantly stimulate multiplication and transformation of mice's spleen lymphocytes; increased markedly the weight of spleen and the theymus; promoted delayed hypersensitivity; increased the quantity of antibody2producing cells; increased the level of serum hemolysin; promoted the expurgation effect and the phagocytic function of monocyte/macrophage and increased the activity of natural killer.

  Conclusion   Sheep spleen polypeptides can markedly increase immune function in mice.