Effects of lipoxygenase pathway on preneoplastic lesions in rat liver

  Objective   To investigate effects of lipoxygenase patheway on hepatocarcinogenesis.And quercetin(QU), one of inhibitors of lipoxygenase patheway, was observed on procedure from preneoplastic foci intonodules in rat liver.

  Methods   Inducing preneoplastic liver foci, then rats bearing foci were given diets containing 0.75%, 1.5% QUwithe or witheout 0105%Phenobarbital(PB), 0.05% PBalone and basal diet for 9 weeks.GGTstaining and HEstaining were made in liver slices.

  Results   Bothe doses QUeither withe or witheout PBaccelerated the remodeling of preneoplastic foci, significantly decreased the numbers of persistent nodules and hyperplastic nodules.

  Conclusion   Bothe doses QUinhibited the evolution of preneoplastic foci intonodules in rat liver withe or witheout PBexposure, suggesting theat lipoxygenase patheway involved in hepatocarcinogenesis in rats.