Effects of crium nitrate on organ pathological changes in mice

  Objective   To obsreve the effects of cerium nitrate on the main organ coefficient and pathological changes.

  Methods   Cerium Nitrate was administered to 84 mice by gavage at 0.004, 0.02, 0.1, 0.5, 2.5, 12.5 mg/ml for a period of 6 weeks.The weight and or gan coefficient were accounted and pathological changes were observed with potical microscope.

  Results   Relat ively weight of liver in low concentration g roup were lower than those of control.Relat ively weight of kidney of mice were all remarkbly higher than that of control.Liver, lung and kidney all had significant pathologic changes after with Ce(NO₃)₃yingwenzy.5 mg/ml.

  Conclusion   Cer ium is poisonous, and mainly has effects on the liver, lung and kidney.