Analysis on T lymphocyte level in patients infected with HBV/HIV and HIV/HBV co-infected

  Objective   To quantitatively and qualitatively analyse the CD3⁺ /CD4⁺ /CD8⁺ T lymphocy te level of patients infected with HBV or HIV, and polyinfected with HBV and HIV.

  Methods   The flow cytometry was used to measure CD3⁺ /CD4⁺ /CD8⁺ and CD4⁺ /CD8⁺ ratio of 31 patients infected with HBV, 46 patients infected with HIV, 14 patients polyinfected with HBV and HIV and 18 normal controls.

  Results   All markers of HIV/HBV polyinfection group, HIV infection group, HBV infection group and normal control group had statistics differ entiations with each other(F=50.67, F= 46.06, F=16.13, F=92.51, P < 0.01);Quantity of CD3⁺ cells showed that HIV/HBV group < HIV group < HBV group < normal control(P < 0.01), quantity of CD4⁺ cells was HIV/HBV group < HIV group < HBV group < normal control(P < 0.01), while quantity of CD8⁺ cells was HIV group > HBV group > normal control(P < 0.01).D4+/CD8⁺ ratio is invert, HIV/HBV, HIV group < HBV group < normal control(P < 0.01).

  Conclusion   the detection of absolute quantity of CD4⁺ cells and CD4⁺/CD8⁺ ratio maybe important in evaluating immunecondition, progression and prognosis of patients infected with HIV.moveover, polyinfected with HBV and HIV may hurt the patients immune fundtion more serious.