Study on influence factors of status of non-response to HB vaccine

  Objective   To study the status of non-response to HBVvaccine and the factors of non-responders with HBVvaccine in Guangdong province.

  Methods   2 667 persons were investigated in Guangdong province, non-condition logistic regression analysis was used to analysis the reason of non-responders with HBVvaccine.

  Results   The results of non-responderrate was 25.38% in Guangdong province.Univariate logistic regression analysis indicated that the impact factors of anti-HBs production correlated with age, vaccination, frequency of inoculation, location of inoculation, input medicine made by blood, frequency of disinfection of dishware, fatherwith vaccination and anti-HBs production of parent with vaccination.The result of multivariate logistic regression analysis indicated that dangerous factors were age, fatherwith non-vaccination and heredity factors.

  Conclusion   The impact factors of anti-HBs production correlated with vaccine, foods, individual and heredity factors.