Objective To investigate the relationship between metallothionein 1B(MT1B)gene locus on chromosome 16 and type 2 diabetes mellitus in Chinese Han people.
Methods The PCR-RFLP method was employed to detect the genotypes of MT1B gene in 379 subjects including 146 patients with T2DM(case group)and 232 unrelated healthy individuals.
Results No significant differences were found in the frequencies of allele and genotype of the two SNPs(SNP1 and SNP2)of MT1B gene between the case and the control(P > 0.05).
Conclusion There is no genetic association between the MT1B gene SNP1 and SNP2 polymorphism and T2DM in the Han descent population in the North of China.
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