Expression of Caspase-3 in myocardial cell of carbon disulfide poisoned mice

  Objective   To study the effect of carbon disulfide infection of mice myocar dial cell apoptosis.

  Methods   Forty-eight mice were divided randomly into four groups.Three experimental groups were inbreathed different concentration carbon disulfide with low dosage, middle dosage and high dosage.The blank comparison did not imbibes with it.Five weeks later the myocar dium of the all groups were taken; expression of caspase-3 in the myocar dial cell was measured by S-P immunohistochemistry.

  Results   The expression of the caspase-3 presented the masculine in all groups without blank group.

  Conclusion   The carbon disulfide has poisonous function to myocardial or ganizes in mice, and it can induce the apoptosis of myocardial cell in mice.