A case-control study on Idiopathic Talipes Equinovarus in northeast region of China

  Objective   To investigate the properetiology of Idiopathic Talipes Equinovarus(ITEV)in Liaoning, Jilin and Heilongiang province of China.

  Methods   121 proposita data information were obtained by follow-up and questionnaire survey.220 normal person infor mation matched with control group to complete case-control study for some risk factors of ITEV.

  Results   9 persons were excluded since they had some other defor mities.After this process.112 proposita were involved.The ratio of ITEV between male and female was 2.6:1, and bilateral deformity was seen in 50% or more of ITEV cases.And in unilater al cases, the right side was more often involved than that of left side.There were more ITEV births in summer/winter than that of spring/autumn.Among all environmental factors, taking medicine before or during pregnancy was significant difference between case and control group(χ²=8.64 and 13.49;P < 0.01).And 65.2% mother had abnormal uterus factors in case group, which had significant difference compared with control group(χ²=49.29, P < 0.01).There was no difference in maternal smo king, drinking and having disease during pregnancy between case and control group(P > 0.05).

  Conclusion   Taking medicine before or during pregnancy and abnormal uterus factors may play important roles in etiology of ITEV.