A case-control study on heritability pattern and risk factors of Hepatoma

  Objective   To afford scientific basis on the prevention of hepatoma by exploring the risk factors of hepatoma in and studying on heritability pattern of hepatoma.

  Methods   98 hepatoma cases and 196 health people with controls were interviewed by case-control study and theirex posure history were asked.It was studied on the hereditary epidemiology of genealogy of 98 hepatoma cases by using Penrose method, simple segregation analysis method and Falconer method.

  Results   The ratio ratio were respectively 5.18, 8.40, 2.16, 9.33, 2.56 and 2.61 of history of hepatitis Bdisease, history of relative's sumor, history of eating salt bloating foo d, history of hepatocirrhosis, drinking surface water and shallow water, and drinking.Monogenic doinant simple segregation analysis(Segregation ratio was 0.5)χ² =219144, P < 0.01.Monogenic dominant recessive segregation analysis(Segregation ratio was 0.25)χ²=67.74, P < 0.01.Using Penrose method to calculate the hepatoma occurring ratio of brethren, the hepatoma occurring ratio of everyman(s/q)was close to 1/q ^1/2.The hereditary degree of class Ikinfolks of proband was 58.74% ±5.43%.

  Conclusion   History of hepat itis Bdisease, history of relative's tumor, history of eating salt bloating food, history of hepato cirrhosis, drinking surface water and shallow shallow water, and drinking were the risk factors of hepatoma in WuWei.Hereditary of proband hepatoma was polyg ene.Hereditary factor was 0.60 of total risk factors of hepatoma.