Evaluation on immune response effects of two oral hepatits A vaccines

SHAO Congwen; HOU Zongliu; XU Donglei

doi:10.11847/zgggws2006-22-07-60

SHAO Congwen, HOU Zongliu, XU Donglei, . Evaluation on immune response effects of two oral hepatits A vaccines[J]. Chinese Journal of Public Health, 2006, 22(7): 864-865. DOI: 10.11847/zgggws2006-22-07-60

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Evaluation on immune response effects of two oral hepatits A vaccines

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Abstract

Objective To study the immune effects of live attenuated HAV vaccine(H₂)and inactiv ated hepatitis A vaccine(L8).
Methods The Balb/c mice were orally immunized, and the total anti-HAV antibody, IgA, sIgA; Tlymphocyte subsets of blood; lymphocytes proliferation; IFN-C, TNF-A and IL-2 of sera of mouse were detected.
Results Both HAV vaccine could induce humoral, cellular and local immune response after mice orally immunized.But aluminiferous inactivated HAV vaccine had better cellular response with lower antibody level.
Conclusion Oral immunizat ion can be an effective way of inducing both local and systemic immunity ag ainst HAV.

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Evaluation on immune response effects of two oral hepatits A vaccines

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