Objective To study the relationship between survivin(the new member of inhibition apoptosis protein family)expression and the biological behaviors of colorectal cancer, the relationship between survivin expression and bcl-2 expression, ki-67 label index.
Methods Immunohistochemical SP method was used to examine the single and joint expression of survivin, bcl-2 proteins, and the ki-67 label index in cancer tissue and marge tissue.
Results (1) The positive rates of survivin expression were 63.6% in cancer tissue and 0% in marge tissue respectively.The difference between the rates was significant (P < 0.01).Surviv in expression didnt have significant relationship with patient age, differentiation grade, tumor size, tumor location, Dukes stage and lymph node metastasis(P > 0.05), but had significant relationship with sex of colorectal cancer patients(P < 0.05).(2)The bcl-2 expression didnt have significant relationship with the surviv in expression(P > 0.05).(3) The mean ki-67 label index in survivin positive tumors was significantly higher than that of survivin negative tumors(P < 0.01).
Conclusion Survivin plays a certain role in the oncog enesis and prog ression of colorectal cancer by up-regulating cell proliferation; the over expression of surviv in is an independent event in the colorectal cancer tumor igenesis.
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