Study on Xba I locus polymorphism of apolipoprotein B gene among healthy children in Nanning

ObjectiveTo study the distribution characteristics of ApoBgene Xba Ilocus among healthy children in Nanning,and to probe the effect of polymorphism on children's growth,nutritional status,serum lipids metabo lism and renal function.MethodsPolymerase chain reaction-restriction frag ment length polymorphism(PCR-RFLP)technique was used to analyze the Xba I genotypes of ApoB gene among 126 healthy children in Nanning,body mass indexes(BMI),serum levels of total protein(TP),albumin(AIB),globulin(GLO),A/G,lipoprotein a(LPa),total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),non-HDL,low-density lipoprotein cholesterol(LDL-C),ApoA1,ApoB,ApoA1/B, blood urea nitrogen(BUN),creatinine clearance rate(Ccr)and uric acid(UA)were detected.Results(1)The distr ibution of the Xba Ig enotypes were X-/X-:92.06% (116/126),X+/X-:7.14% (9/126),X+/X+:0.79% (1/126);and the allele frequencies were X-:92.06% (116/126),X+:7.94% (10/126);(2)The serum levels of TP、AIB、A/G and ApoA1/B among X+children were lower than those in X-children,while BMI、LPa、TC、TG、non-HDL、LDL-C、ApoB、BU Nand Ccr of X+were higher than X-significantly.ConclusionThe Xba I locus polymorphism of apolipoprotein B gene can affect children's growth,nutritional status,serum lipids metabolism and renal function.