Effects of docosahexaenoic acid compound on activity of TPK in H22 cancer cells of mice

Objective To study the anti-tumor mechanism of DHA compound.Methods The transplanted H₂₂ liver cancer mouse model was used to explore the effect of DHA compound on the activity of tyrosine protein kinase(TP K)in H₂₂cancer cells by using the incorporation ofγ-³² Padenosine triphosphate(ATP)into exogenous substract.Results The antitumor rate of DHA compound was more than 70%.The activity of TP K of nucleolus,cytoplasm membrane,endoplasmic reticulum and mitochondria was elevated significantly in H₂₂ cancer cells(P<0.01),but it decreased obviously after being treated with DHA compound(P<0.01).Conclusion DHA compound could inhibit the activity of TP K and decrease signal conduction with cancer cells.