Study on antimicrobial administration in mastectomy patients during perioperative period

To study the situation of the use of antimicrobials in perioperative patients and to evaluate the rationality of use.Methods To make a survey on the use of antimicrobials in 289 mastectomy patients during the period April 2002～April 2004,and to evaluate the kinds,frequency and combined administration.Results The nosocomial infection rate of mastectomy patients was 1.38%,lower than the local infection rate of perioperative period 1.7%.98.62% patients received antimicrobials involving 8 kinds of drugs,the therapeutic course of 266 patients was more than 3 days.98.33% type I slices patients and 97.87% mastadenoma patients received antimicrobials.The proportion using β-lactams and quinupristin antimicrobials was high.There was a trend using less third-generation of cephalosporins antimicrobials for prophylaxis,in comparison with that in 2002～2003 group the percentage of second-generation of cephalosporins antimicrobials in 2003～2004 was higher(P<0.05);The rate of single antimicrobial,and two,three combined administration was 74.05%,23.83%,1.38% respectively.Conclusion The supervision of using antimicrobials in perioperative period must be reinforced.The following points need to be emphasized:the indication of prophylactics medication of operations;the proper antibiotics for perioperative prophylaxis;the period of postoperative prophylaxis medication and the administration of antibiotics to the operated patients regularly.