Relationship between gene polymorphism of 5-HTR4 as well as GABRG2 and schizophrenia

Objective To investigate the association between schizophrenia and the polymorphism of 5-hydroxytryp-tamine-4 receptor(52HTR4)and gamma-aminobutyric cidreceptor,gamma-2(GABRG2).Methods PCR-restriction fragment length polymorphism(RFLP)was used to examine the C/T single nucleotide polymorphism(SNP)of 5-HTR4 and T/GSNP of GABRG2 with 95 nuclear family trios of schizophrenia.Results The genotype frequency distributions of two SNPs were in the Hard-Weinberg equilibrium.The results of TDT indicated that the allelic frequency transmitted from the heterozygote parents did not deviate 50%.The results of transmission test showed that rs888957-rs211014 haplotype system was not associated with schizophrenia.There was significantly relationship between 52HTR4 allele and delusion of love that was positive symptom of schizophrenia(P<0.01).There was significantly relationship between GABRG2 allele and aggressive behavior(P<0.05).Conclusion As far as Chinese han schizophrenia in this paper is concerned,we may not be assured the association between the polymorphism of 5-HTR4 or GABRG2 and schizophrenia,but we can not be excluded the effect of polymorphism of 5-HTR4 and GABRG2 on psychotic symptoms in schizophrenia.